Preparation and study in vitro of 20 (S)-protopanaxadiol pharmacosomes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 842-846, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-281704
ABSTRACT
To prepare and evaluate in vitro the 20 (S) -Protopanaxadiol (Ppd) pharmacosome. The Ppd pharmacosome was successfully prepared by thin film-dispersion and its stability in vitro was studied. The particle size of pharmacosome was evaluated by dynamic scattering (DLS) and the encapsulation efficiency was determined by using centrifugal ultra-filtration. The encapsulation efficiency of Ppd pharmacosome was (80.84 +/- 0.53)% with the diameter of 100. 1 nm; While the encapsulation efficiency of Ppd pharmacosome that added Brij 78 added was (72.76 +/- 0.63)% with the diameter of 117. 3 nm. In addition, the effect of some factors on the encapsulation efficiency and the particles size, such as temperature, alcohol, pH and artificial gastrointestinal fluids, were investigated respectively. The selected formulation and technology are simple and practical to prepare Ppd pharmacosome and preparation properties are more stable.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Sapogeninas
/
Espalhamento de Radiação
/
Temperatura
/
Química
/
Química Farmacêutica
/
Etanol
/
Estabilidade de Medicamentos
/
Ácido Gástrico
/
Concentração de Íons de Hidrogênio
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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