Effect of griffithin on anticancer activity and apoptosis of cancer cells in vitro / 药学学报
Acta Pharmaceutica Sinica
;
(12): 104-107, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-281917
ABSTRACT
To study the anticancer activity of griffithin from Streptocaulon griffithii Hook. f. and its effect on apoptosis of cancer cells in vitro, the inhibitory effect of griffithin on cell proliferation was studied by MTT assay, the cell apoptosis was observed by AO/EB double decoration assay and flow cytometry. Griffithin exhibited high anticancer activity on four human cancer cell lines, with IC50 ranged from 0.17 - 0.43 microg x mL(-1). Griffithin also induced apoptosis of PC-3 cells. Griffithin had anticancer activity and induced apoptosis of cancer cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Medicamentos de Ervas Chinesas
/
Cardenolídeos
/
Estrutura Molecular
/
Ciclo Celular
/
Sobrevivência Celular
/
Química
/
Apoptose
/
Raízes de Plantas
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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