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Synthesis and antibacterial activity of 3-(4-piperazin-1-yl-phenyl)-s-triazolo 3,4-b 1,3,4 thiadiazole hydrochlorides / 药学学报
Acta Pharmaceutica Sinica ; (12): 54-57, 2007.
Artigo em Chinês | WPRIM | ID: wpr-281927
ABSTRACT
To study the synthetic method and antibacterial activity of water-soluble fused heterocyclic compounds containing piperazine group, the nucleophilic substitution of 3-(4-chlorophenyl)-6-substituted-s-triazolo-[3, 4-b] [1, 3, 4] thiadiazoles (2a - n) with piperazine in the presence of phase transfer catalyst TBAI afforded 3-(4-piperazin-1-yl-phenyl)-6-substituted-s-triazolo [3, 4-b] [1, 3, 4] thiadiazole and then followed by acid treatment afforded 3-(4-piperazin-1-yl-phenyl)-6-substituted-s-triazolo [ 3, 4-b] [1, 3, 4] thiadiazole hydrochlorides (3a - n). Twenty-eight new compounds were synthesized and their structures were confirmed by IR, 1H NMR, MS and element analysis. The in vitro antibacterial activities of all newly synthesized compounds were tested against Gram positive bacteria and Gram negative bacteria with the standard 2-fold agar dilution method. Fourteen title compounds exhibited potential antibacterial activities in vitro. The structures of these compounds needed to be further optimized.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Pseudomonas aeruginosa / Staphylococcus aureus / Relação Estrutura-Atividade / Tiadiazóis / Bacillus subtilis / Triazóis / Estrutura Molecular / Testes de Sensibilidade Microbiana / Química Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Pseudomonas aeruginosa / Staphylococcus aureus / Relação Estrutura-Atividade / Tiadiazóis / Bacillus subtilis / Triazóis / Estrutura Molecular / Testes de Sensibilidade Microbiana / Química Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2007 Tipo de documento: Artigo