A new method for quantitative assessment of mechanisms of partitioning and absorption of drugs: linear solvation energy relationships / 药学学报
Acta Pharmaceutica Sinica
;
(12): 13-18, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-281933
ABSTRACT
Linear solvation energy relationships are of a great value in investigating quantitative structure-retention relationship and quantitative structure-activity relationship, and predicting chromatographic retention indices of drugs. Several quantitative relationships in different in vitro biomembrane-mimetic models between retention factors and molecular descriptors have been established successfully and used to clarify drug-membrane interaction mechanisms. Quantitative structure-activity relationships also have been established to predict drug intestinal absorption, permeation of skin and blood-brain barrier. This review focused on the significance and widely application of linear solvation energy relationships in quantitative assessment for mechanisms of partitioning and absorption of drugs. The discrepancy and limits of linear solvation energy relationships were also discussed, which gives us a better insight into investigation of partitioning and absorption of drugs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Solubilidade
/
Solventes
/
Termodinâmica
/
Farmacocinética
/
Preparações Farmacêuticas
/
Modelos Lineares
/
Química
/
Relação Quantitativa Estrutura-Atividade
/
Absorção Intestinal
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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