Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3 / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1733-1735, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-282100
ABSTRACT
<p><b>OBJECTIVE</b>Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.</p><p><b>METHODS</b>Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.</p><p><b>RESULTS</b>Wolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5.</p><p><b>CONCLUSION</b>The gene of Wolff-Parkinson-White syndrome is located at 7q3.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome de Wolff-Parkinson-White
/
Cromossomos Humanos Par 7
/
Marcadores Genéticos
/
Mapeamento Cromossômico
/
Sequências de Repetição em Tandem
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2002
Tipo de documento:
Artigo
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