Expression of betaig-h3 in keratoconus and normal cornea / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1401-1404, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-282175
ABSTRACT
<p><b>OBJECTIVES</b>To observe the expression of betaig-h3 in normal cornea and keratoconus and to elucidate the role of extracellular matrix in keratoconus.</p><p><b>METHODS</b>In situ hybridization was used to detect the expression of betaig-h3 in the cornea. The cDNA library was screened with human betaig-h3 cDNA probe to locate betaig-h3 mRNA in cells.</p><p><b>RESULTS</b>Expression of betaig-h3 was found mainly in the stroma of the normal cornea and keratoconus, but decrease depending on the degree of keratopathy. In some serious cases, no expression signal was detected. The strongest expression was seen at the border of the normal region and keratoconus.</p><p><b>CONCLUSIONS</b>betaig-h3, the structural component of the extracellular matrix, can affect cell adhensiveness in the development of corneal fibrous interstitial organization. During the development of keratoconus, decreasing levels of betaig-h3 cause the diminution of corneal steadiness, which is related to formation of keratoconus.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cicatrização
/
RNA Mensageiro
/
Proteínas da Matriz Extracelular
/
Fator de Crescimento Transformador beta
/
Córnea
/
Genética
/
Ceratocone
/
Metabolismo
/
Proteínas de Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2002
Tipo de documento:
Artigo
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