Studies on liver-toxicity in rhigoma of Dioscorea bulbifera / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera.</p><p><b>METHOD</b>The rats were randomized into four groups control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope.</p><p><b>RESULT</b>T001 and F002 showed significant liver toxicity.</p><p><b>CONCLUSION</b>The chloroform fraction was the liver-toxic fraction of D. bulbifera.</p>