Protective effect of curcumin on experimental liver injury in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 756-793, 2003.
Article
em Zh
| WPRIM
| ID: wpr-282247
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To Study the protective effect of curcumin on three models of experimental liver injury in mice.</p><p><b>METHOD</b>The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.</p><p><b>RESULT</b>Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.</p><p><b>CONCLUSION</b>Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Aspartato Aminotransferases
/
Sangue
/
Intoxicação por Tetracloreto de Carbono
/
Lipopolissacarídeos
/
Substâncias Protetoras
/
Curcumina
/
Alanina Transaminase
/
Doença Hepática Induzida por Substâncias e Drogas
/
Galactosamina
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2003
Tipo de documento:
Article