Effects of yixintong on regulating cellular calcium channels / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.</p><p><b>METHOD</b>The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.</p><p><b>RESULT</b>Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.</p><p><b>CONCLUSION</b>Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.</p>