Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 816-819, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-282502
ABSTRACT
<p><b>OBJECTIVE</b>To study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE).</p><p><b>METHODS</b>The peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet).</p><p><b>RESULTS</b>The mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01).</p><p><b>CONCLUSION</b>The mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tricloroetileno
/
RNA Mensageiro
/
Estudos de Casos e Controles
/
Expressão Gênica
/
Dermatite Ocupacional
/
Proteínas com Domínio T
/
Alergia e Imunologia
/
Fator de Transcrição GATA3
/
Fatores de Transcrição Forkhead
/
Antígeno CTLA-4
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2011
Tipo de documento:
Artigo
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