Expression of survivin gene in a rat model of acute pancreatitis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1141-1143, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-282600
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of survivin in acute pancreatitis in rats.</p><p><b>METHODS</b>Acute pancreatitis was induced in rats by retrograde injection of sodium taurocholate into the pancreaticobiliary duct. The expressions of survivin in the pancreatic tissues was detected by immunohistochemisty, Western blotting and RT-PCR, and the apoptotic ratio of the acinar cells was determined by TUNEL assay.</p><p><b>RESULTS</b>Survivin was not detected in the control group, and in rat models of acute pancreatitis, the expressions of survivin protein and mRNA increased but the apoptotic index of the acinar cells decreased gradually with the severity of inflammation.</p><p><b>CONCLUSION</b>Survivin is involved in the regulation of acinar cell apoptosis and also the necrosis of the apoptotic acinar cells through its anti-apoptosis activity to aggravate acute pancreatitis, suggesting its value as a promising marker in predicting the severity of acute pancreatitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancreatite
/
Patologia
/
Ácido Taurocólico
/
RNA Mensageiro
/
Biomarcadores
/
Distribuição Aleatória
/
Doença Aguda
/
Ratos Sprague-Dawley
/
Apoptose
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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