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Biocompatibility of polylactic-co-glycolic acid for culturing bFGF gene-transfected bone marrow stromal cells and application of the cell complex for repairing rabbit cartilage defect / 南方医科大学学报
Journal of Southern Medical University ; (12): 1123-1126, 2009.
Artigo em Chinês | WPRIM | ID: wpr-282605
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the biocompatibility of polylactic-co-glycolic acid (PLGA) for culturing bFGF gene-transfected bone marrow stromal cells (BMSCs) and assess the feasibility of this cell complex for repairing cartilage defect in rabbits using tissue engineering method.</p><p><b>METHODS</b>BMSCs transfected by bFGF gene were cultured on PLGA matrix to assess the biocompatibility of PLGA. The cell complex was then implanted into the cartilage defect in rabbits, and its effect in cartilage defect repair was evaluated by histological observation and immunohistochemical staining.</p><p><b>RESULTS</b>BMSCs transfected by bFGF gene grew normally on PLGA matrix. After implantation, the complex showed good effect for cartilage defect repair in rabbits.</p><p><b>CONCLUSION</b>PLGA has good biocompatibility with the transfected BMSCs, and the cell complex can be used for repairing rabbit cartilage defect and may potentially serve as a substitute of cartilage autograft.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácido Poliglicólico / Cirurgia Geral / Ferimentos e Lesões / Materiais Biocompatíveis / Células da Medula Óssea / Transfecção / Cartilagem Articular / Distribuição Aleatória / Engenharia Genética / Células Cultivadas Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácido Poliglicólico / Cirurgia Geral / Ferimentos e Lesões / Materiais Biocompatíveis / Células da Medula Óssea / Transfecção / Cartilagem Articular / Distribuição Aleatória / Engenharia Genética / Células Cultivadas Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2009 Tipo de documento: Artigo