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Study on the relationship between level of CD58 expression in peripheral blood mononuclear cell and severity of HBV infection / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2072-2076, 2005.
Artigo em Inglês | WPRIM | ID: wpr-282821
ABSTRACT
<p><b>BACKGROUND</b>As one of the intercellular adhesion molecules, CD58 plays important roles in promotion of the adhesion between T cells and target cells, hyperplasia, activation of T cells and natural killer cells, and balance between Th1 and Th2. We studied the relationship between the levels of CD58 expression in peripheral blood mononuclear cells (PBMCs) and severity of HBV infection.</p><p><b>METHODS</b>The levels of CD58 mRNA in PBMCs were detected using quantitative reverse transcription PCR. The percentage of CD58 positive cells was detected by flow cytometry in patients and healthy controls.</p><p><b>RESULTS</b>The levels of CD58 mRNA and the percentage of CD58 positive cells in patients infected with HBV were significantly higher than that in the control. Based on severity of HBV infection, the patients were classified into four groups. The expression of CD58 increased significantly in an order from mild chronic, moderate chronic, severe chronic to severe hepatitis groups. The levels of CD58 mRNA and the percentage of CD58 positive cells in PBMCs from patients with HBV infection were both positively correlated with serum levels of ALT and AST.</p><p><b>CONCLUSION</b>The level of CD58 expression is related with the severity of HBV infection and the degree of liver damage.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Sangue / RNA Mensageiro / Leucócitos Mononucleares / Antígenos CD58 / Alanina Transaminase / Genética / Hepatite B / Metabolismo Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Sangue / RNA Mensageiro / Leucócitos Mononucleares / Antígenos CD58 / Alanina Transaminase / Genética / Hepatite B / Metabolismo Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2005 Tipo de documento: Artigo