Comparison of Ondansetron and Droperidol in Reducing Postoperative Nausea and Sedation Associated with Patient-Controlled Analgesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 1164-1169, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-28287
ABSTRACT
BACKGROUND:
To know the effect of droperidol and ondansetron on nausea and sedation in postoperative patients, we studied 120 gynecological patients receiving patient-controlled analgesia (PCA) with morphine and droperidol or ondansetron.METHODS:
Subjects were randomly allocated to one of four groups according to PCA regimen, morphine 0.5 mg/cc alone (group M); morphine plus droperidol 0.034 mg/morphine 1 mg (group D); morphine plus ondansetron 0.132 mg/morphine 1 mg (group O1); morphine plus ondansetron 0.066 mg/morphine 1 mg (group O2). The PCA device, WalkMed was set at basal rate 2 ml/hr (1 mg/hr), bolus dose 1 ml (0.5 mg), lockout time 10min, 1 hour maximum dose 4 mg. The severity of nausea, sedation and pain were assessed at 1h, 4h, 8h, 12h, 24h, and 48h postoperatively.RESULTS:
The occurrence of nausea was not different among groups. But there were statistical differences in the nausea severity (p<0.05). The group D and group O1 had lower nausea scores, and between them there was no difference. The scores for sedation were significantly lower in the group O1 compared with group M and group D (p<0.05). Overall pain scores were not different among groups.CONCLUSIONS:
Ondansetron and droperidol are effective in reducing nausea. Ondansetron is superior to droperidol in avoiding excessive sedation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Anafilaxia Cutânea Passiva
/
Analgesia Controlada pelo Paciente
/
Ondansetron
/
Náusea e Vômito Pós-Operatórios
/
Droperidol
/
Morfina
/
Náusea
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
1997
Tipo de documento:
Artigo
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