Preliminary study of gene expression profiling in human type I and II endometrial carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 734-737, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-282930
ABSTRACT
<p><b>OBJECTIVE</b>To study gene expression profiling in human type I and II endometrial carcinoma.</p><p><b>METHODS</b>Six Affymetrix human genome genechips were utilized to investigate the differences in gene expression profiles between type I and II endometrial carcinoma with bioinformatic analysis.</p><p><b>RESULTS</b>Many genes were highly expressed in estrogen-dependent endometrial carcinoma, and some of them were involved in the metabolism and conversion of estrogen, while some others in estrogen regulation. CYP2C9, for instance, was involved in the conversion of estrogen sulfate to 16-hydroxy sulfate metabolite, DDC in estrogen-dependent pathogenesis of endometrial carcinoma possibly by DDC interaction with AR to enhance steroid receptor transcription.</p><p><b>CONCLUSION</b>High expression of these genes in estrogen-dependent endometrial carcinoma may provide insights into their roles in the pathogenesis and prognosis of this malignancy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Adenocarcinoma
/
Regulação Neoplásica da Expressão Gênica
/
Classificação
/
Neoplasias do Endométrio
/
Adenocarcinoma de Células Claras
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Perfilação da Expressão Gênica
/
Análise em Microsséries
/
Genética
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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