Sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome / 南方医科大学学报
Journal of Southern Medical University
;
(12): 615-616, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-282966
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes of sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome (ARDS).</p><p><b>METHODS</b>After isolation of the AT II cells as ARDS model induced by oleic acid, the whole cell sodium current was recorded in 5 h with patch-clamp in whole-cell mode. The effect of beta2-agonist terbutaline on the current was also examined.</p><p><b>RESULTS</b>The sodium currents recorded from AT II cells in ARDS were smaller than that of the control cells, but the current could be stimulated to increase obviously by terbutaline.</p><p><b>CONCLUSION</b>AT II cells can actively transport sodium ion even under conditions of ARDS, but this capacity can not match that of the control cells. Terbutaline can obviously stimulate the sodium current.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Alvéolos Pulmonares
/
Sódio
/
Síndrome
/
Canais de Sódio
/
Distribuição Aleatória
/
Doença Aguda
/
Ratos Sprague-Dawley
/
Transporte de Íons
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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