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Changes of Substance P in the substantia gelatinosa of the dorsal horn field after liquid nitrogen freezing of severed nerve for prevention of terminal neuroma / 南方医科大学学报
Journal of Southern Medical University ; (12): 1218-1220, 2007.
Artigo em Chinês | WPRIM | ID: wpr-283168
ABSTRACT
<p><b>OBJECTIVE</b>To determine the changes of Substance P in the substantia gelatinosa of the dorsal horn field after transient liquid nitrogen freezing of severed rat sciatic nerve for prevention of terminal neuroma.</p><p><b>METHODS</b>The bilateral sciatic nerves of 20 SD rats were severed, and the left sciatic nerves was subjected to transient liquid nitrogen freezing with the right sciatic nerve as control. After 20 and 28 weeks, the nerve ends were resected and prepared for microscopic examination, and Substance P in the substantia gelatinosa of the dorsal horn field was determined by immunohistochemistry.</p><p><b>RESULTS</b>Typical neuromas occurred in the severed ends of the right sciatic nerves but not in the left sciatic nerves. The distribution and optical density of Substance P in the substantia gelatinosa of the dorsal horn field was significantly smaller in the left than in the right nerves (P<0.05).</p><p><b>CONCLUSION</b>Liquid nitrogen freezing of the severed sciatic nerve results in decreased release of Substance P in the substantia gelatinosa of the dorsal horn field, suggesting that noxious stimulation may increase Substance P release in the substantia gelatinosa of the dorsal horn field.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Nervo Isquiático / Substância Gelatinosa / Ferimentos e Lesões / Substância P / Criopreservação / Química / Ratos Sprague-Dawley / Metabolismo / Métodos Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Nervo Isquiático / Substância Gelatinosa / Ferimentos e Lesões / Substância P / Criopreservação / Química / Ratos Sprague-Dawley / Metabolismo / Métodos Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo