Protective effects and mechanism of hyperin on CoCl2-induced PC12 cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2409-2412, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-283184
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the neuroprotective effects and mechanism of hyperin on CoCl2-induced hypoxic/ischemic PC12 cells.</p><p><b>METHOD</b>CoCl2 was used to treat rat pheochromocytoma cell line (PC12) to investigate the protective effects of different concentrations of hyperin.</p><p><b>RESULT</b>Hyperin could significantly inhibit CoCl2-induced cytotoxicity and apoptosis on PC12 cells in a dose-dependent manner, by inhibiting reactive oxygen species (ROS) production, increasing mitochondrial membrane potential (MMP), and inactivating caspase-3 and poly ADP-ribose polymerase (PARP).</p><p><b>CONCLUSION</b>Hyperin could inhibit CoCl2-induced cytotoxicity and apoptosis on PC12 cells, show neuroprotective effects on hypoxic/ischemic neural injuries.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Quercetina
/
Extratos Vegetais
/
Sobrevivência Celular
/
Células
/
Química
/
Células PC12
/
Cobalto
/
Apoptose
/
Substâncias Protetoras
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
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