Activity evaluation of components and preparation of effective components group of xiaoxuming decoction for anti-cerebral ischemic / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2140-2144, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-283240
ABSTRACT
<p><b>OBJECTIVE</b>On basis of preliminary studies, to prepare the effective components group of Xiaoxuming decoction for anti-ischemic by combining chemical analysis with pharmacological activity screening.</p><p><b>METHOD</b>Free radical scavenging was assayed by DPPH method; the cell viability injured by hydrogen peroxide, L-glutamate, and hypoxia was determined by MTT assay; TBA method was used to determine mitochondrial lipid peroxidation.</p><p><b>RESULT</b>Comprehensive analysis of multi-target results, the comprehensive activities of 40% ethanol elution and the middle layer were the highest.</p><p><b>CONCLUSION</b>40% ethanol elution and the middle layer were proportionally mixed as the effective components group of Xiaoxuming decoction.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Encéfalo
/
Medicamentos de Ervas Chinesas
/
Sobrevivência Celular
/
Sequestradores de Radicais Livres
/
Células PC12
/
Ratos Wistar
/
Ácido Glutâmico
/
Usos Terapêuticos
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
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