Expression of vascular endothelial growth factor C and survivin in gastric carcinoma and their clinical implications / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 264-267, 2006.
Article
em Zh
| WPRIM
| ID: wpr-283340
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of vascular endothelial growth factor C (VEGF-C) and survivin protein in human gastric carcinoma,and to evaluate their clinical implications.</p><p><b>METHODS</b>The expressions of VEGF-C and survivin protein in tumor tissues,matched para- tumor tissues from 97 cases with gastric cancer and normal tissues form 20 normal controls,were determined by immunohistochemistry. Their relationships with clinicopathological parameters were analyzed.</p><p><b>RESULTS</b>The positive rate of VEGF-C and survivin protein in tumor tissues (66.0% and 57.2%) was significantly higher than those in matched para-tumor tissues normal tissues (P< 0.05). There were no significant differences in VEGF-C expression considering tumor size,localization,histological grade,venous invasion,and distant metastasis (P > 0.05), while its expression was correlated with serosal infiltration, lymphatic invasion, lymph node metastasis and TNM stage III-IV (P< 0.05). The survivin expression was significantly related with serosal infiltration,lymphatic invasion, regional lymph node metastasis,distant metastasis, and TNM stage III- IV (P< 0.05), but not with histological grade, localization,venous invasion,and tumor size (P > 0.05). The 1, 3 and 5-year survival rates of the patients with positive VEGF-C or survivin protein were significantly lower than those of the patients with negative VEGF-C or survivin (P< 0.05), respectively. In additional,the expression of VEGF-C was positively correlated with survivin expression in gastric carcinoma (P< 0.01).</p><p><b>CONCLUSION</b>The expressions of VEGF-C and/or survivin may be indicators for poor prognosis of gastric carcinoma.</p>
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Assunto principal:
Patologia
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Prognóstico
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Neoplasias Gástricas
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Carcinoma
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Seguimentos
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Fator C de Crescimento do Endotélio Vascular
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Proteínas Inibidoras de Apoptose
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Metabolismo
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Proteínas Associadas aos Microtúbulos
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Estadiamento de Neoplasias
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2006
Tipo de documento:
Article