Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of Taizhi'an capsule in treatment of hyperlipidemic fatty liver.</p><p><b>METHOD</b>The model rats were induced by feeding high caloric diet for 8 weeks, then fifty rats were randomly divided into five groups, and each group had ten rats, the Taizhi'an groups (high dose 1 000 mg x kg(-1), middle dose 500 mg x kg(-1), low dose 250 mg x kg(-1)), the Yishanfu group and the model group. Liver index (liver weight/body weight), liver function, blood lipid, liver lipid, the content of MDA and SOD in liver were assayed after therapy, and observe Pathologic changes in rats liver.</p><p><b>RESULT</b>Liver index, blood lipid, liver lipid, liver function increased significantly (P < 0.001) in model rats, and the content of SOD in liver decreased significantly (P < 0.05), Liver histology expressed mild to moderate fat denaturation; After being treated with high and middle dose of Taizhi'an capsule for six weeks, blood lipid, liver function decreased significantly (P < 0.001), and liver lipid decreased significantly (P < 0.001, P <0.05), the content of SOD in liver increased significantly (P < 0.05), meanwhile liver histology was closed to normal.</p><p><b>CONCLUSION</b>Taizhian capsule is effective in the treatment of hyperlipidemic induced fatty liver.</p>