Effect on expression of mice alpha-hemoglobin stabilizing protein in different developmental stages treated with Yisui Shengxue granules / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 609-612, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-283422
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the effect of Yisui Shengxue granules on expression of alpha-hemoglobin stabilizing protein (AHSP) mRNA in different developmental stages mice.</p><p><b>METHOD</b>The total RNAs were extracted from the bone marrow karyocyte of normal adult mice and the karyocyte of fetus liver and fetus spleen in pregnanted mice (pregnanted 21 days) and fetal mice (pregnanted 14 days). The expression level of AHSP mRNA in different developmental stages mice interfered with Yisui Shengxue granules was measured by real-time PCR.</p><p><b>RESULT</b>The intervention of Yisui Shengxue granules could significantly up-regulated the expression levels of AHSP mRNA in normal adult mice.</p><p><b>CONCLUSION</b>The result revealed that one of possible molecular mechanism of the effects caused by Yisui Shengxue granules is that it can promote the AHSP gene expression, reduce the free a-globin deposit, then prevent the poison to erythrocyte and decrease the haemolysis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Baço
/
RNA Mensageiro
/
Células da Medula Óssea
/
Medicamentos de Ervas Chinesas
/
Proteínas Sanguíneas
/
Distribuição Aleatória
/
Regulação para Cima
/
Química
Limite:
Animais
/
Gravidez
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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