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Pathological diagnosis and ultrastructure features of primary pulmonary cryptococcosis: a study of 27 cases / 中华病理学杂志
Chinese Journal of Pathology ; (12): 424-428, 2004.
Artigo em Chinês | WPRIM | ID: wpr-283498
ABSTRACT
<p><b>OBJECTIVE</b>To investigate diagnostic histopathology and ultrastructure features of primary pulmonary cryptococcosis (PC).</p><p><b>METHODS</b>Clinical data and pathologic findings of 27 cases of PC were retrospectively reviewed, light and electron microscopic evaluations and histochemistry stain studies were performed.</p><p><b>RESULTS</b>The specimens consisted of 2 fine-needle aspiration lung biopsies and 25 cases of open lung biopsies. Cryptococcosis granuloma formation was identifiable by histopathological examination in 25 of 27 cases, with gum-like lesion and fungi in the remaining 2 cases. The detection rates of cryptococcus neoformans (CN) by mucicarmine (MC), periodic acid-Schiff (PAS), alcian blue (AB) and Grocott methenamine-silver (GMS) were 87.0% (20/23), 100% (27/27), 66.7% (18/27), and 100% (23/23) respectively. Under the electron microscope, most CN had a simple structure with a few organelles. The capsule was seen in all organisms. A percentage of the organisms showed nuclei, nucleoli, mitochondria and vacuoles. The detection rate of CN by EM was 91.7% (11/12).</p><p><b>CONCLUSIONS</b>The clinical manifestation and imaging of PC are nonspecific for PC. Lung biopsy is the major diagnostic modality. The detection rate by electron microscopy was quite high. Therefore, a correct diagnosis of pulmonary cyrptococcosis should rely on the combination of histopathological evaluation, histochemistry staining and/or electron microscopic examination.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Microscopia Eletrônica / Estudos Retrospectivos / Seguimentos / Classificação / Criptococose / Cryptococcus neoformans / Biópsia por Agulha Fina / Diagnóstico Diferencial / Pulmão Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Microscopia Eletrônica / Estudos Retrospectivos / Seguimentos / Classificação / Criptococose / Cryptococcus neoformans / Biópsia por Agulha Fina / Diagnóstico Diferencial / Pulmão Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2004 Tipo de documento: Artigo