Genome-wide genetic study of medulloblastoma using allelotype analysis / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 413-415, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-283501
ABSTRACT
<p><b>OBJECTIVE</b>To investigate global genetic alterations in medulloblastoma, and to localize critical chromosomal loci with allelic imbalances associated with the development of medulloblastoma.</p><p><b>METHODS</b>A high-resolution genome-wide allelotype analysis, including 384 microsatellite markers, was performed in 12 medulloblastomas.</p><p><b>RESULTS</b>An average of 238 (62.3%) allelic imbalances were detected on all 39 autosomal arms. Non-random allelic gains or losses were detected on chromosomes 7q (58.3%), 8p (66.7%), 16q (58.3%), 17p (58.3%) and 17q (66.7%). In addition, chromosomal arms with frequencies of allelic imbalances higher than the mean percentage were identified on 3p (33.3%), 3q (33.3%), 4q (41.7%), 7p (33.3%), 8q (41.7%), 10q (41.7%), 13q (33.3%), 14q (33.3%) and 20q (33.3%). No relationship was found between the frequency of allelic imbalances and the clinical outcome of the patients.</p><p><b>CONCLUSIONS</b>A global view of the genetic alterations in medulloblastoma was provided. The allelic imbalances involving chromosomes 7q, 8p, 16q, 17p and 17q may play an important role in the pathogenesis of medulloblastoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromossomos Humanos Par 7
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Cromossomos Humanos Par 8
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Cromossomos Humanos Par 16
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Cromossomos Humanos Par 17
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Neoplasias Cerebelares
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Repetições de Microssatélites
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Desequilíbrio Alélico
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Alelos
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Genética
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Genótipo
Limite:
Adolescente
/
Adulto
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Criança
/
Criança, pré-escolar
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2004
Tipo de documento:
Artigo
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