Specific regulator of eosinophil apoptosis: Siglec-8-new hope for bronchial asthma treatment / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2048-2052, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-283672
ABSTRACT
<p><b>OBJECTIVE</b>It is known that Siglec-8 is selectively expressed on human eosinophils at a high level and mediates eosinophil apoptosis when crosslinked with its antibody. The aim of our review is to elucidate the molecular and biological characteristic of Siglec-8 and then discuss the function and possible mechanisms of Siglec-8 in eosinophils. Thereby, we will expand our understanding to the regulation of eosinophil apoptosis, and provide important clues to the treatment of asthma and other hyper-eosinophilic diseases.</p><p><b>DATA SOURCES</b>Most articles were identified by searching of PubMed online resources using the key term Siglecs.</p><p><b>STUDY SELECTION</b>Mainly original milestone articles and critical reviews written by major pioneer investigators in the field were selected.</p><p><b>RESULTS</b>Siglec-8 is selectively expressed on human eosinophil and can specifically induce eosinophil apoptosis.</p><p><b>CONCLUSION</b>The restricted expression of Siglec-8 on human eosinophil and the rapid progress in understanding its role as cell signaling and activation of death receptors have made it an attractive target for treatment of asthma and other hyper-eosinophilic diseases.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Asma
/
Terapêutica
/
Apoptose
/
Biologia Celular
/
Eosinófilos
/
Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS