Randomized controlled trial of antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2432-2435, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-283746
ABSTRACT
<p><b>BACKGROUND</b>A prior study showed significant antibiotic resistance to quinolone in our population. In this study we aimed to evaluate and compare the efficacy of a single versus a combined prophylactic antibiotic regimen before transrectal ultrasound-guided prostate biopsy (TRUGPB).</p><p><b>METHODS</b>A prospective randomized study was conducted at a university hospital. Patients undergoing TRUGPB were randomized into an amoxicillin-clavulanate alone (1 mg; one dose before and two doses after biopsy) or an amoxicillin-clavulanate + ciprofloxacin group (250 mg; one dose before and two doses after biopsy). Patients were surveyed for infection symptoms by phone on days 3 and 30 after TRUGPB. We defined an infective complication as the occurrence of symptoms including fever, chills or rigor within 30 days after prostate biopsy, requiring medical treatment or hospitalization, aided by a territory-wide electronic medical record system.</p><p><b>RESULTS</b>Between November 2007 and July 2009, 367 patients were randomized to either amoxicillin-clavulanate alone or amoxicillin-clavulanate + ciprofloxacin group. The infection rates after TRUGPB were 3.91% in the former group (7 out of 179 patients) versus 0.53% (1 out of 188 patients) in the latter. Sixty-three percent (5/8) of patients with infective complications needed hospitalization. There was no intensive care unit admission or mortality during the study period.</p><p><b>CONCLUSIONS</b>Combining prophylactic antibiotics with amoxicillin-clavulanate + ciprofloxacin significantly reduced the incidence of infective complications after TRUGPB. We recommended a combination regimen, especially in centre with high incidence of post-TRUGPB infection.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Próstata
/
Reto
/
Cirurgia Geral
/
Biópsia por Agulha
/
Diagnóstico por Imagem
/
Ciprofloxacina
/
Ultrassonografia
/
Antibioticoprofilaxia
/
Ácido Clavulânico
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo diagnóstico
/
Pesquisa qualitativa
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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