Studies on constituents of rootsanel leaves from Desmodium blandum and their cytotoxic activity against growth of several tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2077-2080, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-283793
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of Desmodium blandum and their cytotoxic activity against the growth of several tumor cells.</p><p><b>METHOD</b>Various chromatographic techniques including silica gel, Sephadex LH-20 column chromatography were employed for the isolation and purification of the constituents. The structures of compounds were elucidated by spectral analyses (IR, UV, NMR, MS). Their cytotoxic activity was then studied.</p><p><b>RESULT</b>Eight compounds were isolated from the stems of D. blandum and identified as N, N-dimethyltryptamine (1), 5-methoxy-N, N-dimethyltryptamine (2), citrusinol (3), yukovanol (4), (Z)-1-(4-hydroxy-2, 3-dimethoxyphenyl)-3-(4-hydroxyphenyl) propene (5), (Z)-1-(3-hydroxy-2, 4-dimethoxy-phenyl)-3-(4-hydroxy-3-methoxy-phenyl) propene (6), methylprotocatechuate (7), katuranin (8).</p><p><b>CONCLUSION</b>Among these compounds, compound 6 was isolated from D. blandum for the first time. In the MTT test, compounds 2 and 6 exhibit cytotoxic activities against the KB cell, and compounds 3 and 6 exhibit the same activities against the HepG2 cell.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Espectrofotometria Infravermelho
/
Derivados de Benzeno
/
Medicamentos de Ervas Chinesas
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
N,N-Dimetiltriptamina
/
Química
/
Folhas de Planta
/
Espectrometria de Massas por Ionização por Electrospray
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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