Release kinetics of oridonin self-microemulsifying drug delivery system in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2049-2052, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-283801
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the release characteristics and mechanism of oridnonin self-microemulsifying drug delivery system (SMEDDS) in vitro.</p><p><b>METHOD</b>The concentration of oridonin was determined by HPLC. In vitro release studies were conducted by reverse dialysis technique. The effects of release medium, agitation rate and preparations on the oridonin release were studied. The similarity factor (f2) was applied to the release profile comparisons. Model fitting was used to determine the kinetics and mechanism.</p><p><b>RESULT</b>The release media and agitation rate from 50-100 r x min(-1) had no distinctive effect on the oridonin release kinetics, which the similarity factors were greater than 50. The oridonin release profiles for oridonin SMEDDS and oridonin ethanol solution were similar. 65% of oridonin were released in 30 min for oridonin SMEDDS in pH 7.8 PBS. Oridonin SMEDDS fit the Hixson-Crowell model best.</p><p><b>CONCLUSION</b>The release data from oridonin SMEDDS showed it release fast. The deduced release mechanism is that the surface and particle sizes of self-microemulsion in water solution are changing during the process of release and the drug penetration through membrane is a passive diffusion process.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cinética
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Sistemas de Liberação de Medicamentos
/
Diterpenos do Tipo Caurano
/
Emulsões
/
Métodos
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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