Investigation on inhibition of HIV III B virus with extractions of Juglans regia / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2535-2538, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-283844
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.</p><p><b>METHOD</b>Phytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.</p><p><b>RESULT</b>Two extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.</p><p><b>CONCLUSION</b>J. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Linhagem Celular
/
Química
/
HIV-1
/
Juglans
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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