Research progress of mechanisms through which dipeptidyl peptidase-4 inhibitors regulate glycemia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 229-233, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-284273
ABSTRACT
Dipeptidyl peptidase-4 (DPP-4) inhibitors are promising new antidiabetic drugs. It had been proposed that DPP-4 inhibitors exert their antidiabetic effect by inhibiting the degradation of glucagon-like peptide 1(GLP-1) . However, new evidence has shown that the increase of GLP-1 is not notable after the use of these drugs in patients with type 2 diabetes. Therefore, the specific mechanisms via which DPP-4 inhibitors in controlling blood glucose has became questionable. In recent years, studies have revealed many possible mechanisms through which DPP-4 inhibitors regulate glycemia DPP-4 inhibitors may selectively reduce DPP-4 activity in the intestine, causing the increase of portal plasma GLP-1 level and thus promoting the release of insulin via nerve reflex;also, they may decrease the cleavage product of GLP-1 and reduce the degradation of other bioactive peptides.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Glicemia
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
/
Peptídeo 1 Semelhante ao Glucagon
/
Inibidores da Dipeptidil Peptidase IV
/
Hipoglicemiantes
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2013
Tipo de documento:
Artigo
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