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Erythropoietin levels in patients with multiple sclerosis complicated with anemia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 84-87, 2013.
Artigo em Chinês | WPRIM | ID: wpr-284299
ABSTRACT
<p><b>OBJECTIVE</b>To explore the potential decrease of serum erythropoietin (EPO) level in patients with multiple sclerosis (MS) complicated with anemia.</p><p><b>METHODS</b>The serum EPO levels were detected in the patients with MS complicated with anemia (MS group, n=31), patients with iron deficiency anemia (IDA group, n=33), and healthy subjects (normal control group, n=80) by enzyme-linked immunosorbent assay (ELISA). Blood routine test, reticulocyte count, hemoglobin, and indexes of liver and kidney function were also detected.</p><p><b>RESULTS</b>The serum EPO level in MS group was significantly lower than those in IDA group [(101.3±17.6)U/L vs.(166.1±8.7)U/L, P<0.01]. Moreover, the serum EPO level decreased as the severity of anemia in the MS group increased it was (95.7±9.6), (101.7±8.1), and (123.7±9.3) U/L in patients with mild, moderate, and severe anemia, respectively (P<0.05). Other indicators including blood routine findings, reticulocyte count, hemoglobin, and liver and kidney function parameters showed no significant difference between the MS group and the IDA group (P>0.05).</p><p><b>CONCLUSIONS</b>The serum EPO level decreases in patients with multiple sclerosis complicated with anemia, and the decreasing levels are related with the severity of anemia. Thus EPO therapy may be beneficial for these patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Estudos de Casos e Controles / Eritropoetina / Anemia / Esclerose Múltipla Tipo de estudo: Estudo observacional Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Estudos de Casos e Controles / Eritropoetina / Anemia / Esclerose Múltipla Tipo de estudo: Estudo observacional Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2013 Tipo de documento: Artigo