Role of chemokine receptor 2 in renal damage induced by deoxycorticosterone acetate-salt hypertension / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 29-35, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-284309
ABSTRACT
<p><b>OBJECTIVE</b>To determine the role of chemokine receptor 2 (CCR2) in the development of salt-sensitive hypertension-induced renal damage.</p><p><b>METHODS</b>We investigated the renal damage induced by uninephrectomy and deoxycorticosterone acetate (DOCA)-salt in mice treated with or without a selective CCR2 antagonist RS504393 for 4 weeks. Sham mice underwent uninephrectomy without receiving DOCA and saline. Systolic blood pressure, urinary excretion of albumin and 8-isoprostane, creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration were measured.</p><p><b>RESULTS</b>DOCA-salt treatment led to increased systolic blood pressure, increased urinary excretion of albumin and 8-isoprostane, decreased creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration compared with the sham mice (P<0.05). All of them were prevented by CCR2 inhibition (P<0.05).</p><p><b>CONCLUSION</b>Blockade of CCR2 prevents renal damage induced by DOCA-salt treatment, suggesting that CCR2-mediated monocyte/macrophage infiltration may contribute to salt-sensitive hypertension-induced renal injury.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cloreto de Sódio na Dieta
/
Modelos Animais de Doenças
/
Toxicidade
/
Receptores CCR2
/
Hipertensão
/
Rim
/
Metabolismo
/
Camundongos Endogâmicos C57BL
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2013
Tipo de documento:
Artigo
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