Advances in research on G protein-coupled inward rectifier K(+) channel gene / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 426-430, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-284355
ABSTRACT
G protein-coupled inward rectifier K(+) channel 4(GIRK4) is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJ5, it is widely distributed in the mammalian heart, brain, and other tissues and organs. Recent studies have demonstrated that the abnormal expression of GIRK4 gene is associated with atrial fibrillation, and meanwhile may be closely related to obesity, metabolic syndrome, and many other clinical conditions. Further research on the role the GIRK4 gene in the pathophysiology of these clinical conditions will definitely facilitate their clinical diagnosis and treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrilação Atrial
/
Síndrome Metabólica
/
Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G
/
Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2012
Tipo de documento:
Artigo
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