Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 822-824, 2008.
Article
em Zh
| WPRIM
| ID: wpr-284381
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).</p><p><b>METHOD</b>Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.</p><p><b>RESULT</b>Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.</p><p><b>CONCLUSION</b>The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Dor
/
Farmacologia
/
Quinolizinas
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Carbenoxolona
/
Química
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Usos Terapêuticos
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Relação Dose-Resposta a Droga
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Tratamento Farmacológico
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Alcaloides
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Analgésicos
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Article