Effects of Siwu tang on serum protein of blood deficiency using proteomic technique / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 420-423, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-284468
ABSTRACT
<p><b>OBJECTIVE</b>To research the effects of Siwu tang on serum protein of blood deficiency using proteomic technique and further explore its potential molecular mechanism to cure blood deficiency.</p><p><b>METHOD</b>The sera of normal, blood deficiency and cured group were collected. Proteomic protocol involving the high resolution two-dimensional polyacryamide gel electrophoresis, the computer-assisted image analysis, and the mass spectrometry was used to detect regulated protein by Siwu tang.</p><p><b>RESULT</b>Compared with normal group, there were 15 proteins changed, in which 11 increased and 4 decreased expressed proteins in sera could be recovered by Siwu tang. The up-regulated proteins involved haptoglobin, clusterin, complement component C4B and GTP binding protein 2, while the down-regulated proteins involved transthyretin and heamoglobin beta.</p><p><b>CONCLUSION</b>Siwu tang could regulate serum protein, which include immunology, apoptosis, DNA injury repair, and blood ingredients. This might be the mechanism of Siwu tang to cure blood deficiency.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Proteínas Sanguíneas
/
Proteômica
/
Tratamento Farmacológico
/
Doenças Hematológicas
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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