Relationship between CD8+ T-cell CD28 expression and TCM differentiation type in patients with chronic aplastic anemia / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 16-18, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-284526
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between CD8+ T-cell CD28 molecular expression in peripheral blood and TCM type in patients with chronic aplastic anemia (CAA).</p><p><b>METHODS</b>Using flow cytometry to detect the CD28 expression in 45 in-patients or out-patients and 24 healthy subjects for control. And the relation with TCM type was analyzed from the immunological aspect.</p><p><b>RESULTS</b>(1) The levels of CD8, CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- were all higher in the CAA patients than those in the healthy subjects (P < 0.05 or P < 0.01). (2) The levels of CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- were all higher in the CAA patients of Shen-Yin deficiency type than those in the CAA patients of Shen-Yang deficiency type (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>(1) The abnormal high expression of peripheral blood co-stimulatory molecules CD28 suggested CD28 disorder may play an important role in immuno-pathogenesis of CAA. (2) The levels of peripheral CD28, CD8+ CD28+ expression and CD8+ CD28+/CD8+ CD28- can be taken as an objective indexes for TCM typing of CAA, which was disordered more severe in patients of Shen-Yin deficiency type than in those of Shen-Yang deficiency type.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença Crônica
/
Deficiência da Energia Yin
/
Deficiência da Energia Yang
/
Classificação
/
Antígenos CD28
/
Linfócitos T CD8-Positivos
/
Diagnóstico
/
Diagnóstico Diferencial
/
Alergia e Imunologia
/
Anemia Aplástica
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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