Correlation between hepatic immunological markers and virus genotype in patients with chronic hepatitis C / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 452-455, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-285101
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hepatic expression of immunological markers relevant to a cytotoxic response in relation to viral genotype.</p><p><b>METHODS</b>The frozen liver biopsies were obtained from 28 HF genotyped patients and made the sections stained. The morphometry was used to analyze the major histocompatibility complex class I (MHC-I), CD8, beta(2)-microglobulin (beta(2) -mG), HFE and CD68 in the stained sections. Biopsy data of response to therapy with interferon were available in 18 cases.</p><p><b>RESULTS</b>CD8+ was usually clustered together and localized in portal tracts and sinusoids, and seen to interact with MHC I positive lining cells. MHC-I and beta(2) -mG were expressed mainly in endothelial and Kupffer cells. HFE was expressed in most round and dendritic CD68+ cells. Patients with virus genotype 3a had higher hepatic MHC-I and HFE expression, and a better sustained response to interferon (IFN) therapy than patients without.</p><p><b>CONCLUSION</b>The MHC-I expression in the liver of patient with chronic hepatitis C virus infection seems to relate to viral-genotype. The hepatic MHC-I and HFE expression are higher in patients with virus genotype 3a than that in patients with non-3a genotype.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Virologia
/
Ensaio de Imunoadsorção Enzimática
/
Antígenos de Diferenciação Mielomonocítica
/
Antígenos de Histocompatibilidade Classe I
/
Antígenos CD
/
Western Blotting
/
Interferons
/
Antígenos CD8
/
Hepacivirus
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2006
Tipo de documento:
Artigo
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