Effects of Coptis chinensis and Evodia rutaecarpa water extract on DMH-induced precancerous lesion of colon / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1185-1188, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-285375
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Coptis chinensis and Evodia rutaecarpa water extract on precancerous lesion of colon induced by DMH and proliferation and apoptosis changes of colon mucosa crypts.</p><p><b>METHOD</b>Precancerous lesion of colon was induced by DMH. The changes of proliferation and apoptosis of colon mucosa crypts were detected by morphological analysis. The numbers of aberrant crypt foci (ACF) were measured by feulgen staining.</p><p><b>RESULT</b>C. chinensis and E. rutaecarpa water extract could significantly inhibit the formation of ACF in model animals. The proliferative crypts were increased obviously in middle and distal colon, and decreased by C. chinensis and E. rutaecarpa water extract. The apoptosis crypts were increased in distal colon but not middle colon. C. chinensis and E. rutaecarpa water extract could promote apoptosis of both middle and distal colon.</p><p><b>CONCLUSION</b>C. chinensis and E. rutaecarpa water extract could significantly inhibit the formation of ACF in model animals. These results indicated that C. chinensis and E. rutaecarpa water extract maybe have an inhibitory and clinically therapeutic effect on colon cancer, which were partly resulted from inhibiting proliferation and promoting apoptosis of crypts in middle and distal colon.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Extratos Vegetais
/
Distribuição Aleatória
/
Química
/
Ratos Wistar
/
Apoptose
/
Neoplasias do Colo
/
Coptis
/
Evodia
/
Proliferação de Células
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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