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Alpha-glucosidase inhibitors from leaves of Forsythia suspense in Henan province / 中国中药杂志
Article em Zh | WPRIM | ID: wpr-285382
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The alpha-glucosidase inhibitory compounds were searched from Forsythia suspense.</p><p><b>METHOD</b>The active compounds were isolated by the method of bioassay-guided in vitro and column chromatographic techniques. The structures of compounds were identified by MS and NMR spectroscopy. The inhibitory kinetics of the isolated compounds were investigated.</p><p><b>RESULT</b>The ethyl acetate extract showed the strongest inhibitory activity, and five active compounds were isolated from this extract. The IC50 value of compound 1-5 were all lower than that of acarbose as positive control. Compound 1, the mixture of 1, 2 and 4 all showed noncompetitive type model on alpha-glucosidase.</p><p><b>CONCLUSION</b>Compound 1-3 as the inhibitors of alpha-glucosidase were reported for the first time. Compound 3 was isolated from the genus for the first time.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Extratos Vegetais / Cinética / Química / China / Folhas de Planta / Forsythia / Inibidores Enzimáticos / Alfa-Glucosidases / Inibidores de Glicosídeo Hidrolases País/Região como assunto: Asia Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Extratos Vegetais / Cinética / Química / China / Folhas de Planta / Forsythia / Inibidores Enzimáticos / Alfa-Glucosidases / Inibidores de Glicosídeo Hidrolases País/Região como assunto: Asia Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2010 Tipo de documento: Article