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Ultrastructure and TUNEL staining on inhibition of Rubus alceaefolius total alkaloids for apoptosis of liver in rat models of acute hepatitis / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1060-1063, 2010.
Artigo em Chinês | WPRIM | ID: wpr-285402
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-apoptosis effects of Rubus alceaefolius total alkaloids in rats with hepatic injury.</p><p><b>METHOD</b>The hepatic injury model of rat was induced by intraperitoneal injection with CCl4. Sixty SD rats were randomly divided into the normal group, the model group, the R. alceaefolius total alkaloids intervened group, and the bifendate intervened group. The expressions of the levels of liver cell apoptosis were determined by TUNEL. Ultrastructures of the liver cells were observed with transmission electron microscope.</p><p><b>RESULT</b>Compared with the model group, the degree of hepatic injury and the positive expressions of apoptosis in liver tissues in the R. alceaefolius total alkaloids intervened groups and the bifendate intervened group were significantly lower.</p><p><b>CONCLUSION</b>R. alceaefolius total alkaloids could reduce the pathological changes and degree of hepatic injury in rats, which may be partially through inhibiting the expressions of apoptosis in liver tissue.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Química / Ratos Sprague-Dawley / Apoptose / Rosales / Marcação In Situ das Extremidades Cortadas / Usos Terapêuticos / Modelos Animais de Doenças / Tratamento Farmacológico Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Química / Ratos Sprague-Dawley / Apoptose / Rosales / Marcação In Situ das Extremidades Cortadas / Usos Terapêuticos / Modelos Animais de Doenças / Tratamento Farmacológico Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2010 Tipo de documento: Artigo