Effectiveness of Antimicrobial Central Venous Catheter for Reducing Catheter Colonization in Major Burn Injured Patients

ABSTRACT

PURPOSE: Central venous catheterization is associated with infection. We evaluated the colonization rate in the two different kinds of central venous catheter (CVC) in patients with major burn injuries. METHODS: Eighty four burn patients with over 20% of total body surface were randomly assigned to undergo catheterization with standard CVC (STD group) or antimicrobial Vantex(R) CVC (VTX group). Following catheter removal, the distal tip was aseptically removed and cultured. Burn injured skin was also cultured. RESULTS: There was no significant difference in characteristic of patients and catheterization, and the severity of burn between the two groups. The overall CVC colonization rate was significantly decreased in VTX group (40.0%, 29.9 in 1,000 catheter-days) compared to STD group (64.1%, 43.9 in 1,000 catheter-days) (P=0.031). In case of the distance between the catheterization site and burn injured skin was less than 10 cm, the CVC colonization rate was higher in STD group compared to VTX group (P=0.015). CONCLUSION: Central venous catheterization with antimicrobial Vantex CVC lowered catheter-related colonization in major burn patients. The decrease in colonization rate with Vantex CVC compared with standard catheter is more dramatic when the distance between burn injured skin and CVC placement site is closer.