cDNA microarray and cluster analysis to identify the significance of immune genes associated with benzene poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 260-262, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-285911
ABSTRACT
<p><b>OBJECTIVE</b>To delineate the immune regulatory pathway of benzene poisoning by using gene expression profile analysis.</p><p><b>METHODS</b>Peripheral white blood cell gene expression profile of 7 benzene poisoning patients, including one aplastic anemia, was determined by microarray. Seven chips from normal workers were served as controls. Cluster analysis of gene expression profile was performed. Differentially expressed immune genes associated with benzene poisoning were determined.</p><p><b>RESULTS</b>Among the 2 779 target genes, 38 genes differentially expressed were identified, including 10 up-regulated genes such as CD59, TRA@, MCP etc, and 14 down-regulated genes such as HLA-DMB, HLA-DQA1, HLA-DPB1, ITGB2, PFC etc. Cluster analysis showed that the expression profiles of 38 genes were associated with benzene poisoning.</p><p><b>CONCLUSION</b>Differentially expressed immune genes may play an important role in the pathogenesis of benzene poisoning.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Intoxicação
/
Benzeno
/
Antígenos HLA-D
/
Estudos de Casos e Controles
/
Análise por Conglomerados
/
Antígenos CD59
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
/
Cadeias beta de HLA-DP
/
Cadeias alfa de HLA-DQ
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2005
Tipo de documento:
Artigo
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