Inhibition of HIV virus-like particles production by BST-2 / 病毒学报
Chinese Journal of Virology
; (6): 319-325, 2011.
Article
em Zh
| WPRIM
| ID: wpr-286035
Biblioteca responsável:
WPRO
ABSTRACT
Recently, BST-2 has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1 and other enveloped viruses by tethering virus particles to the cell surface. Here, we showed that the production of HIV-1 virus-like particles was markedly inhibited by BST-2. Both the transient and stable expressing of BST-2 had the same function and Vpu rescued the release of HIV-1 VLP in the presence of human BST-2. Consistent with a direct tethering mechanism, we confirmed that proteolysis releases restricted virions and further showed that this removed the ectodomain of BST-2 from the cell surface.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Vírion
/
Virologia
/
Replicação Viral
/
Células Vero
/
Antígenos CD
/
Regulação para Baixo
/
Infecções por HIV
/
Linhagem Celular
/
Chlorocebus aethiops
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Virology
Ano de publicação:
2011
Tipo de documento:
Article