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Long-term follow-up of isolated-growth hormone deficiency typeIA: the clinical analysis of 2-sister cases / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 944-946, 2010.
Artigo em Chinês | WPRIM | ID: wpr-286173
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the curative and adverse effect of recombinant human growth hormone (rhGH) in 2 patients with isolated-growth hormone deficiency type IA (IGHDIA), to track sexual development and pregnancy, and reassess the quality of life in the adulthood.</p><p><b>METHOD</b>The authors summarized the data of 2-sister cases with IGHDIA; followed up for assessment of height, weight, blood pressure and sexual development; detected fasting blood lipids, glucose, insulin, insulin growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3); made an investigation of education and occupation, and so on.</p><p><b>RESULT</b>After 6.2 and 7.3 years treatment with rhGH, the two sisters had considerably improved height from -7.8 SDS, -8.8 SDS to -2.6 SDS and -1.3 SDS respectively. No evident side effect was observed. They had normal sexual development and pregnancy. The levels of IGF-1 and IGFBP-3 were still low, in the elder sister they were 46.6 µg/L, 2460 µg/L, and in the younger 52.4 µg/L, 2430 µg/L. No hyperlipidemia, diabetes or obesity occurred.</p><p><b>CONCLUSION</b>Long term therapy with rhGH may improve final adult height of individuals with IGHDIA. They can have normal sexual development and pregnancy. Metabolic syndrome did not occur during the follow-up period.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Seguimentos / Classificação / Hormônio do Crescimento Humano / Irmãos / Usos Terapêuticos / Nanismo Hipofisário Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Criança / Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Seguimentos / Classificação / Hormônio do Crescimento Humano / Irmãos / Usos Terapêuticos / Nanismo Hipofisário Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Criança / Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo