Deacetylase SIRT1 and vascular endothelial function / 中华男科学杂志
National Journal of Andrology
;
(12): 831-834, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-286414
ABSTRACT
Silent information regulator factor 2-related enzyme 1 (Sirtuins 1, SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, which can deacetylate histone and non-histone proteins and other transcription factors, and is involved in the regulation of many physiological functions, including gene transcription, energy metabolism, cell senescence and oxidative stress. Recent studies show that through adjusting the activity of endothelial nitric oxide syntheses (eNOS), p53, forkhead box class O (FOXO) and nuclear factor kappa B (NF-kappaB), SIRT1 can protect the functions of vascular endothelia and nerves in a variety of pathological conditions. Therefore, SIRT1 may be used as a potential therapeutic target of these diseases, particularly erectile dysfunction, which are associated with endothelial dysfunction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Endotélio Vascular
/
NF-kappa B
/
Proteína Supressora de Tumor p53
/
Estresse Oxidativo
/
Óxido Nítrico Sintase Tipo III
/
Fatores de Transcrição Forkhead
/
Sirtuína 1
/
Proteína Forkhead Box O1
/
Disfunção Erétil
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS