Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registry
Journal of Bone Metabolism
;
: 29-32, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-28674
ABSTRACT
BACKGROUND:
Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database.METHODS:
We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR).RESULTS:
Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker.CONCLUSIONS:
Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema de Registros
/
Incidência
/
Prescrições
/
Quadril
/
Fraturas do Quadril
/
Hipotensão Ortostática
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Bone Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo
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