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Ambroxol for the prevention of respiratory distress syndrome in preterm infants: a meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 858-863, 2010.
Artigo em Chinês | WPRIM | ID: wpr-286964
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of ambroxol in the prevention of respiratory distress syndrome (RDS) in preterm infants.</p><p><b>METHODS</b>Electronic searches were performed in the Cochrane Library, PubMED, EMBASE, Chinese CBM, Chinese VIP Database, Chinese Wanfang Database and Chinese CNKI Database up to the year of 2009 for randomized controlled trials (RCT) on ambroxol for the prevention of RDS in preterm infants. The meeting articles related to the RCT were manually searched in Pediatrics and Pediatric Research. Meta analysis was performed for the results of homogeneous studies by the Cochrane Collaboration's software RevMan 5.0.17.</p><p><b>RESULTS</b>Six RCTs involving 823 preterm infants were included, and the quality assessment for the trials demonstrated 1 article as A class, 1 article as B class and 4 articles as C class. The Meta analysis showed that ambroxol administration significantly reduced the incidence of RDS (OR=0.24, 95%CI 0.15 - 0.64, P<0.01), bronchopulmonary dysplasis (BPD, OR=0.41, 95%CI 0.23 - 0.75, P<0.01), intraventricular hemorrhage (IVH, OR=0.39, 95%CI0.24 - 0.64, P<0.01), patent ductus arteriosus (PDA, OR=0.33, 95%CI 0.17 - 0.67, P<0.01) and pulmonary infection (OR=0.24, 95%CI0.14 - 0.38, P<0.01). No adverse events related to the ambroxol treatment were reported.</p><p><b>CONCLUSIONS</b>The current evidence shows that early use of ambroxol can reduce the risk of RDS, BPD, IVH, PDA and pulmonary infection in preterm infants.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome do Desconforto Respiratório do Recém-Nascido / Displasia Broncopulmonar / Recém-Nascido Prematuro / Ensaios Clínicos Controlados Aleatórios como Assunto / Hemorragia Cerebral / Usos Terapêuticos / Permeabilidade do Canal Arterial / Ambroxol Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Humanos / Recém-Nascido Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome do Desconforto Respiratório do Recém-Nascido / Displasia Broncopulmonar / Recém-Nascido Prematuro / Ensaios Clínicos Controlados Aleatórios como Assunto / Hemorragia Cerebral / Usos Terapêuticos / Permeabilidade do Canal Arterial / Ambroxol Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Humanos / Recém-Nascido Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo