Effect of motilin receptor agonist-erythromycin on the glucose responsive neurons in hypothalamus of rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 248-251, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-287044
ABSTRACT
<p><b>AIM</b>In order to explore the mechanism of central motilin-induced feeding behavior, the effects of erythromycin, a motilin receptor agonist, on glucose responsive neurons in hypothalamus were observed.</p><p><b>METHODS</b>Extracellular recordings were made from single neurons in region of lateral hypothalamic area (LHA) and ventromedial hypothalamic nucleus (VMH) in anesthetized rats. On the basis of their responsiveness to intracarotid injection of 0.58 mol/L glucose solution 0.2 ml, glucose-sensitive neurons (GSNs) in LHA and glucoreceptor neurons (GRNs) in VMH were recognized. Effects of intracerebroventricularly (i. c. v.) administration of 4 microg erythromycin on neural activities of glucose responsive neurons and non-glucose responsive neurons were examined. The mixture of EM and GM-109 1 microl were used to GSNs and GRNs which were sensitive to i. c. v. administration of EM.</p><p><b>RESULTS</b>In LHA, EM increased activity of GSNs significantly (P < 0.05 vs non-glucose-sensitive neurons group). Whereas in VMH, EM significantly decreased the activities of GRNs (P < 0.01 vs non-glucoreceptor neurons group). The mixture of EM and GM-109 had no effect on GSNs and GRNs.</p><p><b>CONCLUSION</b>EM, a motilin receptor agonist, can stimulate GSNs in LHA and suppress GRNs in VMH and this may contribute to central motilin's effect on feeding behavior.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Receptores dos Hormônios Gastrointestinais
/
Eritromicina
/
Ratos Wistar
/
Receptores de Neuropeptídeos
/
Receptores de Superfície Celular
/
Biologia Celular
/
Hipotálamo
/
Metabolismo
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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