The effects of simulated hypoxia on the development of hypothalamic CRF and AVP neurons in postnatal rats / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the influence of hypoxia on postnatal developing pattern of hypothalamic corticotropin releasing factor(CRF) and arginine vasopressin (AVP) in male and female neonatal rats.</p><p><b>METHODS</b>The hypoxia was simulated in hypobaric cabin. The content of AVP and CRF was assayed by RIA method.</p><p><b>RESULTS</b>It was showed the female rats had the similar developing process with male rats, either at 2300 m or at 5000 m altitude. When they developed at simulated 5000 m altitude, the content of their hypothalamic CRF was lower than that of control rats on postnatal day 21, while the content of AVP was higher than control on day 21 and 28.</p><p><b>CONCLUSION</b>Maybe the difference of the function between hypothalamic CRF and AVP or/and the incoherence of their developing stage contribute to their particular developing pattern at 5000 m altitude.</p>