Effects of genistein on bone mineralization in ovariectomized rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 86-89, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-287092
ABSTRACT
<p><b>AIM</b>To investigate the effects of genistein on bone mineralization in ovariectomized rats.</p><p><b>METHODS</b>Forty-seven Wistar rats were randomly allocated into six groups sham-operated (sham), ovariectomized (ovx), ovariectomized supplied with diethyl stilbestrol (E, 20 microg x kg bw(-1) x d(-1)) or genistein (25, 50, 100 mg x kg bw(-1) x d(-1)). After the rats had been fed for three months, analysis of the bone mineral density, parameters related to mineralization, bone content of Ca, P, Mg, Mn and Zn and serum concentration of parathyroid calcitonin and estrogen was performed.</p><p><b>RESULTS</b>Bone mineral density, bone Ca, P, Zn and Mg content and serum estrogen concentration in ovariectomized rats were significantly decreased, but mean osteoid width increased, mineralization lag time and osteoid maturation period prolonged compared with sham animals. After three months supplementation to ovariectomized rats, bone Ca, P and Mg content increased, mean osteoid width decreased, mineralization lag time and osteoid maturation period shortened compared with ovariectomized animals.</p><p><b>CONCLUSION</b>Genistein promotes bone mineralization by increasing bone Ca, P, Mg and adjusting serum calcitonin to prevent osteoporosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Reabsorção Óssea
/
Calcificação Fisiológica
/
Ovariectomia
/
Densidade Óssea
/
Ratos Wistar
/
Genisteína
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS